The SoftReach Robotics Project Workshop (Crete on October 16-17, 2023)

  ^{The SoftReach Robotics Project Workshop held in Crete on October 16-17, 2023 discussed the progress of the project and to plan for the next phase of work.}

^{Day one of the SoftReach Robotics Project Workshop was a whirlwind of advancements, with each work package showcasing significant progress:}

• ^{WP2: Unveiled a prototype steerable growing robot alongside simulations and experimental results of its everting cousin, paving the way for precise drug delivery within complex biological environments.}
• ^{WP3: Presented the development of sensor-based navigation and control algorithms, enabling precise robot movement through preoperative maps and multi-channel MRI data.}
• ^{WP4: Focused on the payload design, showcasing origami-like porous scaffolds for improved interaction with target cells and enhanced drug diffusion.}
• ^{WP5: Demonstrated in vivo delivery of the therapeutic agent in a mouse model, comparing TCP-loaded to systemic delivery methods. Behavioural tests, electrophysiological experiments, and cell imaging will follow.}
• ^{WP6: Responsible for system integration and evaluation, using phantoms to test the soft robot's growth and attachment. User interface software development is underway based on system specifications and imaging data.}
• ^{WP7: Management of the project activities, disseminating results, and planning the future outreach initiatives, including participation in scientific meetings and workshops.}

^{In the afternoon, the participants took a tour of the IMBB Lab, where the bulk of the SoftReach research is being conducted, allowing to gain invaluable insights into the project's technical backbone.}

^{Day two of the SoftReach Robotics Project Workshop saw a dive into the frontiers of research, with talks exploring novel therapeutic approaches and innovative engineering solutions.}

• ^{Drug and Stem Cell Delivery: Biomaterial scaffolds, akin to origami masterpieces, were proposed for targeted delivery of microneurotrophins and neural stem cells. Challenges of miniaturisation and optimising biomaterial interaction with ependymal cells were addressed, paving the way for a more precise and controlled delivery system.}
• ^{Tackling Alzheimer's: The potential of SoftReach robots to target adult neurogenesis in Alzheimer's disease was a captivating highlight. This ground-breaking approach, if successful, could change the lives of millions suffering from dementia and Alzheimer's by inhibiting neurodegeneration and promoting neural regeneration.}
• ^{Hybrid Imaging Techniques: The discussion ventured into the realm of hybrid optical and optoacoustic imaging, combining microscopy, mesoscopy, and tomography. This innovative approach holds promise for revolutionising vascular and retinal imaging, opening doors to earlier diagnoses and improved treatment options.}
• ^{Evaluating Robotic Performance: Achieving accurate evaluation of the soft robot's capabilities within the brain remains a crucial challenge. Researchers explored the development of state-of-the-art brain phantoms that mimic tissue characteristics like force sensing, cerebrospinal fluid flow, and realistic stiffness. Overcoming challenges in phantom design, including laser welding and polymer surface processing, was emphasised.}
• ^{Navigating Complex Environments: New ideas for steering the robot emerged, with a focus on a dynamic model that accounts for friction, abrupt transitions, and "jittering" movements. This model seeks to enhance the robot's manoeuvrability and adaptability within the intricate biological landscapes it will navigate.}

    ^{With the intense meeting agenda, the presentation and talks allowed for animated discussions and new ideas to be formed.}

  ^{The whole team appreciates the hospitality of the Crete researchers and their dedicated work in organising this meeting. We are looking forward to the next six months of hard work and planning our next meeting. The meeting will be held in spring 2024  in Cyprus.}

^{https://www.linkedin.com/posts/soft-reach-865333274_softreach-robotics-project-workshopsummary-activity-7123279855592353792-2kuN?utm_source=share&utm_medium=member_desktop} 

^{KJ Procyk. 25th October 2023}